An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Overexpression of the c-myc oncogene contributes to the development of a significant number of human cancers. In response to deregulated Myc activity, the p53 tumor suppressor is activated to promote apoptosis and inhibit tumor formation. Here we demonstrate that p53 induction in response to Myc overexpression requires the ataxia-telangiectasia mutated (ATM) kinase, a major regulator of the cel...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2017
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-15-1462